A 55-year-old man with HIV infection has been on antiretroviral therapy for 3 years with a CD4+ count of 487 cells/μL and undetectable viral load until 6 months ago. He now presents for follow-up, and repeat testing shows an HIV RNA level of 1,240 copies/mL. Genotypic resistance testing reveals mutations in the HIV pol gene conferring reduced susceptibility to darunavir and ritonavir. The patient's current regimen includes these two agents plus tenofovir and emtricitabine. Which of the following viral processes is most directly impaired by the mechanism of action of the drugs to which resistance has developed?
- A)Reverse transcription of viral RNA into DNA
- B)Integration of viral DNA into the host chromosome
- C)Proteolytic cleavage of viral polyproteins into functional enzymesGABARITO
- D)Binding of viral envelope glycoproteins to CD4 and coreceptors
- E)Nuclear export of newly synthesized viral RNA
Explicação
Darunavir and ritonavir are HIV protease inhibitors that target the HIV protease enzyme (encoded by the pol gene), which cleaves the Gag-Pol polyprotein into functional components including mature protease, reverse transcriptase, and integrase. Mutations in th... Ver explicação completa e trilha adaptativa →