A 59-year-old man with schizophrenia on haloperidol develops confusion, diffuse lead-pipe rigidity, and diaphoresis 3 days after a dose increase. Vital signs show temperature 39.8°C, heart rate 118/min, blood pressure 156/92 mmHg, and respiratory rate 22/min. Serum creatine kinase is 3,200 U/L. Reflexes are normal. Which of the following best distinguishes this condition from serotonin syndrome?

1. A)Onset within minutes of ingestion is more typical of neuroleptic malignant syndrome
2. B)Lead-pipe rigidity and dopamine blockade are more typical of neuroleptic malignant syndromeGABARITO
3. C)Hyperreflexia and clonus are more typical of neuroleptic malignant syndrome
4. D)Exposure to monoamine oxidase inhibitors is more typical of neuroleptic malignant syndrome
5. E)Mydriasis and diarrhea are more typical of neuroleptic malignant syndrome