A 32-year-old woman with a 2-year history of systemic lupus erythematosus presents with nephrotic syndrome and hematuria. Laboratory studies show positive ANA, low C3/C4 levels, and serologic evidence of anti-dsDNA antibodies. Kidney biopsy demonstrates subendothelial immune deposits on electron microscopy. Which of the following lupus nephritis classes is most likely?
- A)Class V (membranous)
- B)Class IV (diffuse proliferative)GABARITO
- C)Class VI (advanced sclerosing)
- D)Class II (mesangial proliferative)
- E)Class III (focal proliferative)
Explicação
Class IV (diffuse proliferative) lupus nephritis is the most severe form and presents with nephrotic range proteinuria, hematuria, and active urinary sediment. Subendothelial deposits on electron microscopy are characteristic of Class IV and are associated wit... Ver explicação completa e trilha adaptativa →