A 14-year-old boy presents with persistent hematuria and progressive high-frequency sensorineural hearing loss. Ophthalmologic examination reveals anterior lenticonus. Vital signs show BP 128/82 mmHg, HR 88 bpm, RR 16, temp 37°C, SpO2 98% on room air. Serum creatinine is 1.1 mg/dL. Urinalysis demonstrates dysmorphic red blood cells and red blood cell casts; proteinuria is absent. He denies recent URI or skin infection. Which diagnosis best explains this clinical triad?
- A)Alport syndromeGABARITO
- B)IgA nephropathy
- C)Thin basement membrane disease
- D)Membranous nephropathy
- E)Minimal change disease
Explicação
Alport syndrome is a hereditary nephritis caused by mutations affecting type IV collagen, most commonly X linked. Hematuria combined with sensorineural hearing loss and ocular abnormalities such as anterior lenticonus is highly characteristic. Ver explicação completa e trilha adaptativa →