A 19-year-old college student presents with acute onset of severe headache, neck stiffness, and petechial rash. Vital signs show temperature 39.2°C, HR 118/min, BP 102/68 mmHg, RR 22/min, and SpO2 98% on room air. Cerebrospinal fluid reveals elevated protein (180 mg/dL) and positive Gram-negative diplococci cultures confirming bacterial meningitis. His medical history is notable for recurrent meningococcal infections. Which lipid-related complement protein is most likely deficient?
- A)Apolipoprotein C-III
- B)Cholesteryl ester transfer protein
- C)Properdin
- D)Lipoprotein lipase
- E)ApoE in HDL particlesGABARITO
Explicação
Recurrent meningococcal infections are associated with deficiency of the alternative complement pathway. ApoE in HDL particles serves as a ligand for the C3b receptor and is essential for efficient complement-mediated opsonization of bacteria. HDL-bound apoE f... Ver explicação completa e trilha adaptativa →