A 52-year-old woman with mixed dyslipidemia and hypertension (BP 148/92 mmHg, HR 78) starts niacin for lipid lowering. Shortly after each dose, she develops intense facial flushing, pruritus, and mild tachycardia (HR 92). Lipid panel shows total cholesterol 285 mg/dL and triglycerides 320 mg/dL. She denies angioedema or urticaria. When she takes aspirin 325 mg before niacin dosing, symptoms significantly improve. Which medication most likely caused these adverse effects?
- A)Colestipol
- B)Ezetimibe
- C)Atorvastatin
- D)Gemfibrozil
- E)NiacinGABARITO
Explicação
Niacin lowers VLDL synthesis and decreases LDL while increasing HDL. A classic adverse effect is cutaneous flushing mediated by prostaglandins, which can be reduced by pretreatment with aspirin. Ver explicação completa e trilha adaptativa →