A 45-year-old woman presents with joint pain, morning stiffness lasting 2 hours, and swelling in her hands and feet bilaterally. Laboratory studies show elevated rheumatoid factor and anti-CCP antibodies. Histology of a synovial biopsy reveals lymphocyte and plasma cell infiltration with synovial hyperplasia. Which of the following pathologic findings is most characteristic of this condition?
- A)Calcium pyrophosphate dihydrate crystal formation in cartilage
- B)Fibrinoid necrosis of medium-sized arteries with fibrin deposition
- C)Pannus formation with granulation tissue eroding cartilage and boneGABARITO
- D)Monosodium urate crystal deposition within synovial fluid
- E)Hyperplasia of synovial lining with minimal inflammatory infiltrate
Explicação
Rheumatoid arthritis is characterized by pannus formation—a proliferation of synovial tissue containing inflammatory cells that invades and destroys articular cartilage and subchondral bone. The presence of RF and anti-CCP antibodies confirms the diagnosis. Ver explicação completa e trilha adaptativa →