A 48-year-old woman presents with progressive bilateral leg edema and frothy urine for 6 weeks. Vital signs show BP 138/88 mmHg, HR 82/min, RR 16/min, temp 37°C. Laboratory studies reveal nephrotic-range proteinuria (8.2 g/24 hours), serum albumin 2.1 g/dL, and positive anti-phospholipase A2 receptor antibodies. Urinalysis shows no hematuria. She denies fever or recent infections. Which renal biopsy finding is most likely present?
- A)Mesangial IgA deposition
- B)Wire-loop lesions with anti-dsDNA antibodies
- C)Subepithelial immune complex deposits with spike and dome appearanceGABARITO
- D)Diffuse foot process effacement with normal light microscopy
- E)Linear IgG deposition along the basement membrane
Explicação
Primary membranous nephropathy is strongly associated with antibodies to the phospholipase A2 receptor on podocytes. Renal biopsy typically shows diffuse capillary wall thickening and subepithelial immune complex deposits producing a spike-and-dome appearance ... Ver explicação completa e trilha adaptativa →