A 68-year-old man with chronic kidney disease stage 3 presents with nephrotic syndrome and hypercoagulability. Serum albumin is 2.1 g/dL and urine protein exceeds 8 g/day. Kidney biopsy shows uniform thickening of the glomerular basement membrane without inflammation. Immunofluorescence reveals IgG and C3 along the basement membrane in a granular pattern. Which of the following is the most likely diagnosis?
- A)Membranous nephropathyGABARITO
- B)Focal segmental glomerulosclerosis
- C)Diffuse proliferative glomerulonephritis
- D)Minimal change disease
- E)IgA nephropathy
Explicação
Membranous nephropathy presents with nephrotic syndrome and is the most common cause of secondary nephrotic syndrome in adults. Kidney biopsy shows uniform basement membrane thickening with subepithelial 'spike and dome' deposits. Immunofluorescence demonstrat... Ver explicação completa e trilha adaptativa →