A 59 year old man with refractory lymphoma enrolls in a phase 2 trial with 3 treatment arms. After a planned interim analysis, the arm with the lowest response rate is dropped and subsequent participants are randomized only among the remaining arms according to the prespecified protocol. Which design feature does this best illustrate?
- A)Adaptive trial designGABARITO
- B)Crossover trial
- C)Allocation concealment
- D)Block randomization
- E)Case cohort sampling
Explicação
Adaptive trial designs allow prespecified modifications based on interim data while the trial is ongoing. Dropping an inferior arm after a planned analysis is a classic adaptive feature. This can improve efficiency, but the adaptations must be planned in advan... Ver explicação completa e trilha adaptativa →