A 45-year-old woman with systemic lupus erythematosus presents with acute confusion, hallucinations, and transient focal motor deficits. Vital signs: BP 148/92, HR 102, RR 20, Temp 37.8°C, SpO2 98% on room air. Brain MRI reveals multiple white matter lesions. CSF analysis demonstrates lymphocytic pleocytosis with normal glucose levels. Serum antiphospholipid antibodies are positive. She denies fever or recent infections. Which of the following is the most likely diagnosis?

  1. A)CNS lupus vasculitis
  2. B)Thrombotic thrombocytopenic purpura
  3. C)Secondary progressive MS
  4. D)Demyelinating disease associated with SLEGABARITO
  5. E)Antiphospholipid antibody-induced stroke

Explicação

SLE is associated with demyelinating disease including MS-like presentations. The combination of white matter lesions, CSF pleocytosis, acute neuropsychiatric symptoms, and SLE diagnosis suggests SLE-associated demyelination. This can occur independently of an... Ver explicação completa e trilha adaptativa →

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