A 67-year-old man with type 2 diabetes mellitus and hypertension recently started a new antidiabetic agent. He presents with orthostatic lightheadedness, 3-kg weight loss, and recurrent genital candidiasis. Vital signs show BP 118/72 mmHg (down from baseline 145/88), HR 88/min, and normal temperature. Serum glucose is 145 mg/dL (improved from 280 mg/dL), but urinalysis demonstrates glucosuria. He denies polyuria beyond baseline. Which of the following medications most likely caused these findings?
- A)Glyburide
- B)Sitagliptin
- C)Pioglitazone
- D)Metformin
- E)EmpagliflozinGABARITO
Explicação
Empagliflozin causes glucosuria by blocking proximal tubular glucose reabsorption, which leads to osmotic diuresis, weight loss, orthostatic symptoms, and genital mycotic infections. This cluster of adverse effects is highly characteristic of the SGLT2 inhibit... Ver explicação completa e trilha adaptativa →