A cancer screening program detects numerous tumors with excellent 10-year survival rates. However, interval cancers discovered between screening visits in asymptomatic patients demonstrate aggressive behavior with significantly worse outcomes. Chart review shows screened tumors have mean diameter 1.2 cm versus 3.8 cm for interval cancers. Lead time to diagnosis averages 2 years in screened cohorts. Patients with screened tumors remain asymptomatic at detection. Which bias most likely explains the apparently favorable survival statistics in the screened population?
- A)Berkson bias
- B)Measurement bias
- C)Attrition bias
- D)Length-time biasGABARITO
- E)Observer-expectancy bias
Explicação
Length-time bias occurs because screening is more likely to detect slowly progressive diseases that remain in a detectable preclinical phase for longer periods. Rapidly progressive tumors become symptomatic between screening intervals and are underrepresented ... Ver explicação completa e trilha adaptativa →