A 62-year-old postmenopausal woman with osteoporosis presents with progressive lower back pain for three months. Vital signs: BP 128/76, HR 78, RR 16, Temp 37°C, SpO2 98%. Recent DEXA scan shows a T-score of -2.8 at the lumbar spine, and serum calcium is 9.4 mg/dL. Physical examination reveals mild thoracic kyphosis. She has a first-degree relative with breast cancer and denies vaginal bleeding. She seeks a medication that reduces vertebral fracture risk while lowering breast cancer risk without causing endometrial stimulation. Which of the following drugs best meets this goal?
- A)RaloxifeneGABARITO
- B)Calcitonin
- C)Alendronate
- D)Teriparatide
- E)Tamoxifen
Explicação
Raloxifene is a selective estrogen receptor modulator that acts as an estrogen agonist in bone and antagonist in breast and endometrium. It can improve bone density while reducing breast cancer risk without the endometrial stimulation seen with tamoxifen. Ver explicação completa e trilha adaptativa →