A 17 year old boy with cystic fibrosis has worsening wheezing and cough despite adherence to airway clearance therapy. He has low grade fever, eosinophilia, and markedly elevated serum IgE. Sputum culture repeatedly grows Aspergillus species, and chest CT shows central bronchiectasis. Which of the following is the most likely diagnosis?
- A)Hypersensitivity pneumonitis from mold exposure
- B)Invasive aspergillosis
- C)Allergic bronchopulmonary aspergillosisGABARITO
- D)Aspergilloma within a healed tuberculous cavity
- E)Acute eosinophilic pneumonia
Explicação
Allergic bronchopulmonary aspergillosis is correct. Patients with asthma or cystic fibrosis can develop a hypersensitivity reaction to colonizing Aspergillus, causing wheezing, eosinophilia, elevated IgE, and central bronchiectasis. The process is immunologic ... Ver explicação completa e trilha adaptativa →