A 35-year-old woman with poorly controlled type 2 diabetes presents with acute abdominal pain and eruptive xanthomas. Vital signs: BP 138/82, HR 102, RR 18, Temp 37.2°C, SpO2 98%. Laboratory findings reveal fasting glucose 280 mg/dL, triglycerides 450 mg/dL, HDL 28 mg/dL, and lipemic (milky) serum. LDL cannot be calculated. Liver function tests are normal. Which lipoprotein particle is primarily responsible for her clinical presentation?
- A)VLDL
- B)IDL
- C)LDL
- D)HDL
- E)ChylomicronsGABARITO
Explicação
Severe hypertriglyceridemia (>400 mg/dL) with milky serum and eruptive xanthomas indicates chylomicronemia. In uncontrolled diabetes, impaired lipoprotein lipase activity and insulin deficiency reduce triglyceride clearance, allowing chylomicrons (secreted pos... Ver explicação completa e trilha adaptativa →