A 63-year-old man with hypertension (on lisinopril) undergoes colectomy for stage II colon cancer. On postoperative day 6, vital signs are stable (BP 138/82, HR 88, RR 16, temp 37.2°C, SpO2 98%). His surgical wound demonstrates appropriate healing without erythema or drainage. Microscopic examination reveals numerous newly formed capillaries at the wound edge. Hemoglobin is 10.2 g/dL. Which growth factor most directly promotes endothelial cell proliferation and migration in this wound healing phase?
- A)Platelet factor 4
- B)Transforming growth factor beta
- C)Epidermal growth factor
- D)Vascular endothelial growth factorGABARITO
- E)Interferon gamma
Explicação
VEGF is a key driver of angiogenesis during wound healing, promoting endothelial proliferation, migration, and increased vascular permeability. New capillary formation is a central feature of granulation tissue in the early repair phase. Ver explicação completa e trilha adaptativa →