A 20-week gestation fetus is delivered after spontaneous abortion. Physical examination reveals microcephaly, microphthalmia, cleft lip and palate, polydactyly (six fingers bilaterally), and dextrocardia. Maternal history is significant for poorly controlled diabetes mellitus (HbA1c 10.2%) throughout the first trimester. Maternal serologies are negative for TORCH infections. Which chromosomal abnormality most likely accounts for this constellation of congenital malformations?

1. A)Trisomy 21
2. B)Trisomy 18
3. C)45, XO
4. D)5p-
5. E)Trisomy 13GABARITO