A 58-year-old woman with a 10-year history of hypertension presents to the emergency department with acute-onset right-sided hemiparesis and expressive aphasia. Symptoms began 4 hours ago while she was at home. Vital signs: BP 168/94 mmHg, HR 88/min, RR 16/min, temp 37.2°C, SpO2 98% on room air. Non-contrast CT head is unremarkable with no evidence of hemorrhage or acute ischemic changes. Labs show INR 0.98, platelet count 245,000/μL, and glucose 98 mg/dL. Carotid duplex ultrasound demonstrates severe left internal carotid artery (ICA) stenosis (>70%) with irregular, ulcerated plaque. The patient is not on anticoagulation therapy. Which of the following is the most appropriate next step in management?
- A)Administer intravenous alteplase and proceed to urgent carotid endarterectomy within 24 hoursGABARITO
- B)Initiate aspirin therapy and defer carotid intervention pending repeat imaging in 4 weeks
- C)Start unfractionated heparin anticoagulation and schedule carotid endarterectomy within 2 weeks
- D)Perform urgent carotid angiography followed by endovascular stent placement
- E)Administer intravenous alteplase alone without carotid intervention at this time
Explicação
This patient has acute ischemic stroke (symptom onset <4.5 hours ago) with ipsilateral severe, symptomatic ICA stenosis with ulcerated plaque. Current guidelines support thrombolytic therapy (alteplase) for acute stroke within the treatment window, followed by... Ver explicação completa e trilha adaptativa →