A 52-year-old man with resistant hypertension uncontrolled on lisinopril and hydrochlorothiazide is started on a centrally acting sympatholytic agent at 0.1 mg twice daily. Two weeks later, he presents with dry mouth, daytime somnolence, and mild bradycardia (HR 58/min). Current vital signs show BP 128/76 mmHg, temperature 37.1°C, and RR 14/min. Physical examination reveals mildly reduced salivation and no peripheral edema. Laboratory studies reveal normal electrolytes and renal function. He denies orthostatic symptoms. Which medication was most likely prescribed?

  1. A)Phenoxybenzamine
  2. B)Metoprolol
  3. C)ClonidineGABARITO
  4. D)Hydralazine
  5. E)Prazosin

Explicação

Clonidine is a central alpha 2 agonist that lowers blood pressure by decreasing sympathetic outflow. Sedation and dry mouth are classic adverse effects of this mechanism. Ver explicação completa e trilha adaptativa →

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