A 58-year-old woman presents with painless generalized lymphadenopathy and fatigue. Vital signs show HR 88 bpm, BP 128/82 mmHg, temp 37.2°C, RR 16, SpO2 98%. Labs reveal hemoglobin 11.2 g/dL with normal leukocyte count. Lymph node biopsy demonstrates follicular architecture with centrocytes and centroblasts. Cytogenetic analysis identifies t(14;18) translocation. No fever or night sweats reported. Which mechanism best explains how this translocation promotes lymphomagenesis?
- A)Fusion protein that activates ABL kinase
- B)Overexpression of a protein that inhibits apoptosisGABARITO
- C)Loss of a transcription factor that promotes differentiation
- D)Constitutive activation of a tyrosine kinase receptor
- E)Mismatch repair deficiency causing microsatellite instability
Explicação
Follicular lymphoma is classically associated with t(14;18), which places BCL2 under the immunoglobulin heavy chain promoter. BCL2 overexpression inhibits apoptosis, allowing accumulation of long lived neoplastic B cells. Ver explicação completa e trilha adaptativa →