A 28-year-old G2P1 woman at 20 weeks gestation presents to the emergency department with a 2-day history of fever (38.5°C), myalgias, and mild nausea. She reports recent consumption of unpasteurized soft cheese at a restaurant. Vital signs are notable for blood pressure 118/76 mmHg, heart rate 92/min, respiratory rate 16/min, and oxygen saturation 98% on room air. Physical examination is unremarkable with no nuchal rigidity. Blood cultures grow a gram-positive rod that is catalase-positive and demonstrates tumbling motility at room temperature (25°C). Cerebrospinal fluid culture is negative. The patient has not yet been started on antibiotics. Which of the following is the most likely serious fetal/neonatal consequence if maternal infection is not treated promptly?

  1. A)Neonatal tetanus and maternal lockjaw
  2. B)Amnionitis progressing to fetal loss and neonatal meningitis if delivery occursGABARITO
  3. C)Congenital cataracts and cardiac defects from vertical transmission
  4. D)Maternal toxic shock syndrome with fetal demise from hypotension
  5. E)Neonatal conjunctivitis and pneumonia only without CNS involvement

Explicação

The gram-positive rod with catalase-positivity and cold-enriched motility (tumbling at room temperature) is Listeria monocytogenes, a classic cause of maternal-fetal infection. L. monocytogenes readily crosses the placental barrier, causing intrauterine infect... Ver explicação completa e trilha adaptativa →

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