A 28-year-old G2P1 woman at 20 weeks gestation presents to the emergency department with a 2-day history of fever (38.5°C), myalgias, and mild nausea. She reports recent consumption of unpasteurized soft cheese at a restaurant. Vital signs are notable for blood pressure 118/76 mmHg, heart rate 92/min, respiratory rate 16/min, and oxygen saturation 98% on room air. Physical examination is unremarkable with no nuchal rigidity. Blood cultures grow a gram-positive rod that is catalase-positive and demonstrates tumbling motility at room temperature (25°C). Cerebrospinal fluid culture is negative. The patient has not yet been started on antibiotics. Which of the following is the most likely serious fetal/neonatal consequence if maternal infection is not treated promptly?
- A)Neonatal tetanus and maternal lockjaw
- B)Amnionitis progressing to fetal loss and neonatal meningitis if delivery occursGABARITO
- C)Congenital cataracts and cardiac defects from vertical transmission
- D)Maternal toxic shock syndrome with fetal demise from hypotension
- E)Neonatal conjunctivitis and pneumonia only without CNS involvement
Explicação
The gram-positive rod with catalase-positivity and cold-enriched motility (tumbling at room temperature) is Listeria monocytogenes, a classic cause of maternal-fetal infection. L. monocytogenes readily crosses the placental barrier, causing intrauterine infect... Ver explicação completa e trilha adaptativa →