A 45-year-old woman with moderate osteoarthritis presents with knee pain (7/10). Vital signs: BP 128/82, HR 82, RR 16, Temp 37.2°C, SpO2 98%. Her rheumatologist compares two experimental analgesics in clinical trials. Drug X produces greater maximal pain relief than drug Y, reducing her pain to 2/10 at higher doses. However, drug Y achieves 50% of its maximum effect at a substantially lower dose. She denies nausea or drowsiness with either agent. Which pharmacokinetic property best distinguishes drug X from drug Y?
- A)Higher efficacy and lower potencyGABARITO
- B)Higher potency and lower efficacy
- C)Lower bioavailability and higher volume of distribution
- D)Higher therapeutic index and lower clearance
- E)Noncompetitive antagonism with increased receptor number
Explicação
Efficacy refers to the maximal effect a drug can produce, whereas potency refers to the dose required to produce a given effect. Drug X has a greater maximal effect, so it has higher efficacy, but because drug Y reaches 50% effect at a lower dose, drug Y is mo... Ver explicação completa e trilha adaptativa →