A 36-year-old woman with Graves disease started on methimazole 3 weeks ago presents with fever (38.9°C), severe pharyngitis, and cervical lymphadenopathy. Vital signs show HR 102/min, BP 118/76 mmHg, RR 18/min, SpO2 98% on room air. Laboratory studies reveal WBC 1.8 × 10³/μL with neutropenia. She denies rash or joint pain. Which of the following is the most likely explanation for her acute presentation?
- A)Pheochromocytoma
- B)Adrenal crisis
- C)Central hypothyroidism
- D)AgranulocytosisGABARITO
- E)Thyroid storm
Explicação
Methimazole and PTU can rarely cause agranulocytosis, presenting with fever and pharyngitis due to severe neutropenia. Ver explicação completa e trilha adaptativa →