A cyanotic neonate presents at 6 hours of life with oxygen saturation 78% on room air, heart rate 165 bpm, and respiratory rate 58/min. The mother took lithium throughout pregnancy for bipolar disorder management. Echocardiography demonstrates apical displacement of dysplastic tricuspid valve leaflets into the right ventricle with severe regurgitation. Chest X-ray shows cardiomegaly and decreased pulmonary vascular markings. The infant has no audible murmur. Which maternal medication is most strongly associated with this cardiac defect?
- A)Valproic acid
- B)LithiumGABARITO
- C)Methimazole
- D)Warfarin
- E)Isotretinoin
Explicação
Ebstein anomaly is characterized by apical displacement of the tricuspid valve into the right ventricle and is classically associated with maternal lithium exposure. The malformed valve causes tricuspid regurgitation and right atrial enlargement. Cyanosis may ... Ver explicação completa e trilha adaptativa →