A 9-year-old boy presents with progressive gait instability and decreased vibratory sensation in lower extremities. He has chronic steatorrhea and failure to thrive. Vital signs show BP 95/60, HR 88, RR 18, temp 37°C. Peripheral blood smear reveals acanthocytes. Serum cholesterol is markedly decreased at 95 mg/dL. He denies vision problems. He has never taken fat-soluble vitamin supplements. Deficiency of which vitamin most likely explains his neurologic and hematologic findings?

  1. A)Vitamin K
  2. B)Vitamin B1
  3. C)Vitamin D
  4. D)Vitamin A
  5. E)Vitamin EGABARITO

Explicação

This child likely has abetalipoproteinemia with fat malabsorption and vitamin E deficiency. Vitamin E deficiency causes hemolytic anemia and posterior column and spinocerebellar dysfunction due to oxidative injury to neuronal membranes. Acanthocytosis and stea... Ver explicação completa e trilha adaptativa →

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