A 70-year-old woman with recurrent ventricular tachycardia was started on a medication that markedly prolongs phase 3 repolarization. One year later, she presents with progressive dyspnea, photosensitive skin changes, and elevated transaminases (AST 145 U/L, ALT 128 U/L). Vital signs show BP 128/76, HR 82, RR 20, SpO2 92% on room air. Chest X-ray reveals pulmonary fibrosis. She denies orthopnea. Which drug is most likely responsible?
- A)Hydralazine
- B)Adenosine
- C)Nifedipine
- D)Dobutamine
- E)AmiodaroneGABARITO
Explicação
Amiodarone is a class III antiarrhythmic with broad channel blocking properties. Pulmonary fibrosis, hepatotoxicity, corneal deposits, thyroid dysfunction, neuropathy, and blue gray skin discoloration are classic toxicities. Ver explicação completa e trilha adaptativa →