A 51-year-old woman presents with vaginal bleeding and pelvic pain. Vital signs show BP 128/82 mmHg, HR 92/min, RR 16/min, temp 37.2°C. Pelvic ultrasound reveals a large heterogeneous uterine mass measuring 12 cm. Pathology demonstrates atypical spindle cells with 25 mitoses per 10 high-power fields. Immunohistochemistry shows negative CD117 and DOG1 stains. The pathologist suspects leiomyosarcoma. Which marker would most likely stain positive in these tumor cells?
- A)CD20
- B)GFAP
- C)TTF 1
- D)Synaptophysin
- E)DesminGABARITO
Explicação
Desmin is an intermediate filament found in muscle cells and is commonly positive in smooth muscle tumors such as leiomyoma and leiomyosarcoma. The uterine spindle cell morphology supports this lineage. Ver explicação completa e trilha adaptativa →