A 6-year-old boy presents with early pubic hair development and accelerated linear growth. Vital signs show BP 148/92 mmHg, HR 88/min, RR 18/min, temperature 37°C. Laboratory studies reveal low cortisol (3 μg/dL), suppressed plasma renin activity, and markedly elevated DHEA-S (580 μg/dL). Serum glucose is normal. Abdominal imaging shows no masses. Which enzyme deficiency best explains these findings?
- A)21 hydroxylase
- B)17 alpha hydroxylase
- C)5 alpha reductase
- D)11 beta hydroxylaseGABARITO
- E)Aldosterone synthase
Explicação
11 beta hydroxylase deficiency decreases cortisol synthesis and diverts precursors toward androgen production, causing precocious puberty or virilization. Deoxycorticosterone accumulates upstream and acts as a mineralocorticoid, producing hypertension and low ... Ver explicação completa e trilha adaptativa →