A 60-year-old male smoker with a 40 pack-year history presents with progressive proximal leg weakness and dry mouth over 3 weeks. Vital signs show BP 138/82 mmHg, HR 92/min, RR 16/min, temp 37.0°C, SpO₂ 94% on room air. Deep tendon reflexes are diminished but transiently improve after repeated muscle contraction. Serum calcium is normal. Chest CT reveals a 3-cm central lung mass. Cranial nerves are intact. Which diagnosis best explains these findings?
- A)Lambert-Eaton myasthenic syndromeGABARITO
- B)Botulism
- C)Polymyositis
- D)Guillain-Barre syndrome
- E)Myasthenia gravis
Explicação
Lambert-Eaton myasthenic syndrome is the correct answer because it is a paraneoplastic disorder, often linked to small cell lung carcinoma, caused by antibodies against presynaptic voltage-gated calcium channels and characterized by facilitation with repeated ... Ver explicação completa e trilha adaptativa →