A 45-year-old man presents with episodic severe headaches, diaphoresis, and palpitations. Vital signs show BP 168/102 mmHg, HR 118 bpm, RR 16/min, temp 37.2°C. Physical examination reveals no focal neurologic deficits. A CT scan identifies a 3-cm left adrenal mass. Plasma free metanephrines are markedly elevated at 420 pg/mL (normal <90). The patient takes no antihypertensive medications. A pathology report notes the tumor arose from chromaffin cells. Which embryologic origin corresponds to the normal tissue from which this tumor developed?
- A)Surface ectoderm
- B)Intermediate mesoderm
- C)Paraxial mesoderm
- D)Endoderm
- E)Neural crestGABARITO
Explicação
Chromaffin cells of the adrenal medulla are derived from neural crest. Tumors such as pheochromocytoma and neuroblastoma arise from this lineage. Ver explicação completa e trilha adaptativa →