A 48-year-old woman with systemic sclerosis presents with progressive dyspnea, tight shiny skin over her fingers, and positive anti-topoisomerase I antibodies. Vital signs show BP 128/82, HR 98, RR 22, SpO2 92% on room air. High-resolution CT chest reveals early interstitial lung fibrosis. She denies orthopnea. Recent PFTs demonstrate reduced DLCO at 65% predicted. Pulmonary function testing is most likely to show which of the following?
- A)Decreased FEV1 FVC ratio and increased TLC
- B)Decreased TLC and decreased DLCOGABARITO
- C)Normal DLCO with isolated obesity pattern
- D)Increased residual volume with normal diffusion
- E)Normal spirometry with elevated DLCO
Explicação
Diffuse systemic sclerosis can cause interstitial lung disease, producing a restrictive defect with reduced total lung capacity and reduced DLCO. Interstitial fibrosis thickens the alveolar membrane and impairs gas transfer. The anti topoisomerase I antibody a... Ver explicação completa e trilha adaptativa →