A 24-year-old woman with photosensitivity, oral ulcers, and polyarthritis presents with hematuria and proteinuria. Vital signs show BP 138/88 mmHg, HR 92/min, RR 16/min, temperature 37.2°C, SpO2 98% on room air. Laboratory studies reveal serum creatinine 1.2 mg/dL, low C3 and C4 complement levels, and positive anti-dsDNA antibodies. Urinalysis shows no casts. Renal biopsy demonstrates diffuse proliferative glomerulonephritis with characteristic wire-loop capillary lesions. Which diagnosis best explains these findings?
- A)IgA nephropathy
- B)Amyloidosis
- C)Minimal change disease
- D)FSGS
- E)Diffuse proliferative lupus nephritisGABARITO
Explicação
Diffuse proliferative lupus nephritis is the most common and severe form of lupus nephritis and is strongly associated with anti-dsDNA antibodies and hypocomplementemia. Immune complex deposition causes a nephritic picture, and wire-loop lesions reflect subend... Ver explicação completa e trilha adaptativa →