A 15-year-old boy presents with persistent microscopic hematuria discovered on routine urinalysis. He is hypertensive (BP 145/92 mmHg) with normal renal function (creatinine 0.9 mg/dL, eGFR 95 mL/min/1.73m²). His mother reports several male relatives developed progressive kidney failure in their teens. Physical examination reveals sensorineural hearing loss and anterior lenticonus bilaterally. He denies gross hematuria or edema. Which of the following is the most likely underlying defect?
- A)Deficiency of nephrin
- B)Mutation of polycystin genes
- C)Mesangial IgA deposition
- D)Defect in type IV collagenGABARITO
- E)Subepithelial immune complex deposition
Explicação
Defect in type IV collagen is correct. Alport syndrome is an inherited nephritis caused by abnormal basement membrane collagen, leading to hematuria, sensorineural hearing loss, and ocular abnormalities such as lens changes. Progressive renal failure develops ... Ver explicação completa e trilha adaptativa →