A 25-year-old man presents to his primary care physician with a 3-day history of painful grouped vesicles on the shaft of the penis associated with mild fever, malaise, and tender inguinal lymphadenopathy. He reports a new sexual partner two weeks prior and denies any similar episodes in the past. His temperature is 38.1°C, heart rate is 88/min, blood pressure is 122/76 mmHg, and respiratory rate is 16/min. Physical examination reveals multiple 2–3 mm fluid-filled vesicles on an erythematous base along the penile shaft, with no urethral discharge. PCR of the vesicular fluid confirms herpes simplex virus type 2 infection. He is started on a guanosine analog that must first be phosphorylated by viral thymidine kinase and subsequently inhibits viral DNA polymerase by acting as a chain terminator. Which of the following drugs was most likely prescribed?
- A)Zidovudine
- B)Ribavirin
- C)AcyclovirGABARITO
- D)Foscarnet
- E)Oseltamivir
Explicação
Acyclovir is a guanosine analog activated initially by viral thymidine kinase, which gives it selective activity against HSV and VZV infected cells. The triphosphate form inhibits viral DNA polymerase and causes chain termination. The genital vesicular eruptio... Ver explicação completa e trilha adaptativa →