A 27-year-old woman with chronic hypertension (BP 152/98 mmHg) taking an antihypertensive medication becomes pregnant. At her first prenatal visit, the drug is discontinued due to risk of fetal renal malformations, oligohydramnios, and skull hypoplasia. Laboratory studies reveal elevated maternal creatinine at 1.4 mg/dL. Fetal ultrasound shows decreased amniotic fluid volume. She denies proteinuria. Which antihypertensive drug most likely caused these teratogenic concerns?
- A)Nifedipine
- B)Labetalol
- C)Hydralazine
- D)LisinoprilGABARITO
- E)Methyldopa
Explicação
ACE inhibitors such as lisinopril are contraindicated in pregnancy because fetal renin angiotensin system blockade impairs renal development, leading to oligohydramnios and associated malformations. The other listed agents are commonly used in pregnancy. Ver explicação completa e trilha adaptativa →