A 58 year old man is brought to the emergency department after taking a large amount of propranolol in a suicide attempt. He is lethargic. Pulse is 36 per minute and blood pressure is 72 over 40 mm Hg. ECG shows sinus bradycardia. Intravenous fluids and atropine provide minimal improvement. Administration of which of the following is most likely to improve this patient's condition?
- A)Pralidoxime
- B)Naloxone
- C)GlucagonGABARITO
- D)Physostigmine
- E)Protamine sulfate
Explicação
Glucagon increases intracellular cyclic AMP in cardiac myocytes independently of beta adrenergic receptors. In severe beta blocker overdose with bradycardia and hypotension, it can improve heart rate and contractility when adrenergic pathways are blocked. Ver explicação completa e trilha adaptativa →