A 37-year-old woman with pyelonephritis (BP 128/82, HR 98, Temp 38.2°C, WBC 14,200/μL, positive urine nitrites) is treated with ciprofloxacin. One week later, she presents with acute heel pain and swelling after jogging. Physical examination reveals Achilles tendon tenderness without rupture. The physician warns about fluoroquinolone-associated tendinopathy. Which of the following best describes the mechanism of action of this drug class?
- A)Binding to the 30S ribosomal subunit causing misreading of mRNA
- B)Inhibition of peptidoglycan transpeptidation
- C)Inhibition of bacterial DNA gyrase and topoisomerase IVGABARITO
- D)Binding ergosterol to form membrane pores
- E)Inhibition of folate synthesis through dihydrofolate reductase only
Explicação
Fluoroquinolones inhibit bacterial DNA gyrase and topoisomerase IV, impairing DNA replication. They are associated with tendinopathy, QT prolongation, and cartilage toxicity, making the Achilles pain a classic clue. Ciprofloxacin also has important activity ag... Ver explicação completa e trilha adaptativa →