A 58-year-old woman with recurrent sinusitis and hemoptysis presents with rapidly progressive renal failure. Vital signs: BP 152/94 mmHg, HR 102, RR 22, Temp 37.2°C, SpO2 94% on room air. Urinalysis reveals RBC casts and dysmorphic RBCs; serum creatinine is 3.8 mg/dL (baseline 0.9). Chest X-ray shows pulmonary infiltrates. Renal biopsy demonstrates crescent formation with minimal immune deposition on immunofluorescence. She denies antibiotic use. Which antibody is most likely positive?
- A)Anti-mitochondrial antibody
- B)c-ANCA against proteinase 3GABARITO
- C)Anti-SSA antibody
- D)Anti-centromere antibody
- E)Anti-phospholipase A2 receptor antibody
Explicação
Pauci-immune crescentic glomerulonephritis is strongly associated with ANCA-associated small vessel vasculitides. Granulomatosis with polyangiitis commonly presents with upper airway disease, pulmonary hemorrhage, and rapidly progressive GN and is associated w... Ver explicação completa e trilha adaptativa →