A 41-year-old woman is brought to the emergency department by her roommate after being found unresponsive on the couch approximately one hour ago. An empty prescription bottle labeled for a sedative-hypnotic medication was found nearby. On arrival, she is somnolent but arousable to sternal rub, with slurred speech and mild ataxia when attempting to sit upright. Her vital signs reveal a blood pressure of 118/74 mmHg, heart rate of 88 beats per minute, respiratory rate of 10 breaths per minute, and oxygen saturation of 94% on room air. Pupils are 3 mm bilaterally and reactive to light. There is no evidence of nystagmus or clonus. A urine toxicology screen returns positive for benzodiazepines only, with no other substances detected. Which of the following is the most appropriate antidote?
- A)N acetylcysteine
- B)Naloxone
- C)Physostigmine
- D)FlumazenilGABARITO
- E)Pralidoxime
Explicação
Flumazenil is a competitive antagonist at the benzodiazepine binding site on the GABA A receptor and can reverse isolated benzodiazepine overdose. It is used cautiously because it can precipitate seizures in mixed overdoses or chronic users. Ver explicação completa e trilha adaptativa →