A 54 year old man with alcohol use disorder is brought to the emergency department for confusion and difficulty walking. Examination reveals horizontal nystagmus, ophthalmoplegia, and ataxia. He is given intravenous dextrose before vitamin replacement, and his mental status worsens. Deficiency of which of the following cofactors most likely caused this presentation?
- A)Folate
- B)Vitamin C
- C)Riboflavin
- D)Biotin
- E)ThiamineGABARITO
Explicação
This patient has Wernicke encephalopathy due to thiamine deficiency. Thiamine is a required cofactor for pyruvate dehydrogenase, alpha ketoglutarate dehydrogenase, branched chain ketoacid dehydrogenase, and transketolase, so deficiency impairs cerebral energy ... Ver explicação completa e trilha adaptativa →