A 27-year-old woman undergoes partial hepatectomy for living-donor liver transplantation to her brother. Three weeks postoperatively, she reports right upper quadrant fullness but denies abdominal pain, fever, or jaundice. Vital signs are normal (BP 118/76, HR 78, RR 14, Temp 37.0°C). Ultrasound demonstrates restoration of resected liver mass to near-baseline volume with normal echotexture. Serum AST and ALT are mildly elevated but trending downward. Which of the following best explains this rapid hepatic restoration?
- A)Hypertrophy of hepatocytes without DNA synthesis
- B)Hyperplasia of stable cells stimulated to proliferate after injuryGABARITO
- C)Metaplasia of hepatocytes into bile duct epithelium
- D)Regeneration by permanent cells that cannot reenter the cell cycle
- E)Dysplasia due to increased mitotic rate after surgery
Explicação
Hepatocytes are stable cells that usually remain in G0 but retain the capacity to reenter the cell cycle when stimulated by injury or partial hepatectomy. Regeneration of liver mass therefore occurs through compensatory hyperplasia rather than metaplasia or ne... Ver explicação completa e trilha adaptativa →