A 23-year-old woman presents to the emergency department 10 hours after intentional acetaminophen overdose. She reports nausea and right upper quadrant pain. Vital signs show BP 102/68 mmHg, HR 88/min, RR 16/min, temperature 37.2°C. Laboratory studies reveal AST 1200 U/L, ALT 1400 U/L, and INR 1.1. Abdominal ultrasound shows no ascites. She denies prior liver disease or regular alcohol use. Which medication is the most appropriate antidote?
- A)Vitamin K
- B)N acetylcysteineGABARITO
- C)Flumazenil
- D)Methylene blue
- E)Naloxone
Explicação
Acetaminophen overdose causes hepatotoxicity through accumulation of the toxic metabolite NAPQI when glutathione stores are depleted. N acetylcysteine replenishes glutathione and is the antidote of choice. Ver explicação completa e trilha adaptativa →