A 72-year-old man presents with slowly progressive proximal weakness over 2 years, affecting stair climbing and grip strength. Vital signs: BP 138/82, HR 88, RR 16, Temp 37.2°C, SpO2 98%. Serum CK is mildly elevated at 650 U/L. Muscle biopsy shows endomysial inflammation with rimmed vacuoles and acid-phosphatase positive inclusions. No dysphagia or cardiac involvement noted. Which of the following is the most likely diagnosis?
- A)Dermatomyositis
- B)Inclusion body myositisGABARITO
- C)Guillain-Barré syndrome
- D)Polymyositis
- E)Myotonic dystrophy
Explicação
Inclusion body myositis is a chronic inflammatory myopathy of older adults that commonly affects both quadriceps and finger flexors. Rimmed vacuoles on biopsy and poor response to immunosuppression are characteristic. Ver explicação completa e trilha adaptativa →