A 35-year-old female and her husband seek genetic counseling before attempting to conceive. The patient suffers from a particular condition and wants to know the chances that her child will be affected. The pedigree is shown below (shows X-linked pattern with affected males across generations). Based on the mode of inheritance, this patient most likely suffers from which of the following diseases?

1. A)Neurofibromatosis
2. B)Leber hereditary optic neuropathyGABARITO
3. C)Glucose-6-phosphate dehydrogenase deficiency
4. D)Tay-Sachs disease
5. E)Sickle cell anemia