A 46-year-old man with type 2 diabetes and diabetic nephropathy presents with persistent albuminuria despite HbA1c of 6.8%. Vital signs: BP 148/92 mmHg, HR 88/min, RR 16/min, Temp 37°C, SpO2 98%. Urinalysis shows 2+ proteinuria; serum creatinine is 1.1 mg/dL. He denies edema. His physician initiates lisinopril to reduce intraglomerular pressure. This renoprotective effect is most directly mediated by dilation of which of the following vascular structures?
- A)Afferent arteriole
- B)Interlobular artery
- C)Vasa recta
- D)Descending limb of Henle
- E)Efferent arterioleGABARITO
Explicação
ACE inhibitors preferentially dilate the efferent arteriole, lowering intraglomerular capillary pressure and reducing protein filtration. This hemodynamic effect is beneficial in diabetic nephropathy and other proteinuric kidney diseases. Ver explicação completa e trilha adaptativa →