A 23 year old woman comes to the emergency department with recurrent episodes of severe abdominal pain and swelling of the lips and tongue. She has no urticaria or pruritus. Symptoms have not improved with antihistamines or epinephrine during prior episodes. Laboratory studies show low C4 levels. Which of the following is the most likely underlying problem?
- A)Excess histamine release from mast cells due to IgE cross linking
- B)Deficiency of terminal complement proteins
- C)Autoantibodies against desmoglein 3
- D)Preformed recipient antibodies against donor antigens
- E)Deficiency of C1 esterase inhibitor leading to increased bradykininGABARITO
Explicação
Hereditary angioedema is caused by C1 esterase inhibitor deficiency, which leads to excess bradykinin production and recurrent nonpitting edema without urticaria. Low C4 and lack of response to histamine directed therapy are classic clues. Ver explicação completa e trilha adaptativa →