A 19-year-old woman with known peanut allergy accidentally ingests a dessert containing peanuts. Within minutes, she develops diffuse urticaria, wheezing, and lightheadedness. Vital signs show BP 88/52 mmHg, HR 118/min, RR 22/min, and SpO2 92% on room air. Serum tryptase level is elevated at 8.5 ng/mL. She denies angioedema. Which pathophysiologic mechanism most likely produced this acute systemic reaction?
- A)Complement deficiency with recurrent infections
- B)Bradykinin release from contact system activation
- C)IgE mediated mast cell degranulation with histamine releaseGABARITO
- D)Immune complex deposition in postcapillary venules
- E)Cytotoxic T cell injury via perforin
Explicação
Anaphylaxis is an immediate type I hypersensitivity reaction caused by allergen cross linking of IgE bound to mast cells and basophils. Rapid degranulation releases histamine and other mediators, leading to bronchospasm, vasodilation, increased vascular permea... Ver explicação completa e trilha adaptativa →