A 5-year-old girl presents with periorbital and lower extremity edema and frothy urine 2 weeks after viral upper respiratory infection. Vital signs: BP 118/76 mmHg, HR 98/min, RR 22/min, Temp 37.2°C, SpO2 98% on room air. Serum albumin is 2.1 g/dL with nephrotic-range proteinuria (8.5 g/24 hours). Urinalysis shows no hematuria. Her nephrologist initiates empiric therapy without renal biopsy because the most likely disorder characteristically responds dramatically to which of the following treatments?
- A)Plasmapheresis
- B)ACE inhibitor monotherapy only
- C)Cyclophosphamide
- D)Broad-spectrum antibiotics
- E)High-dose corticosteroidsGABARITO
Explicação
Minimal change disease is strongly associated with a brisk response to corticosteroids, especially in children with nephrotic syndrome. This steroid responsiveness is a classic teaching point and often reduces the need for biopsy in typical pediatric presentat... Ver explicação completa e trilha adaptativa →