A 30-year-old pregnant woman with HIV infection started on zidovudine (AZT) for vertical transmission prophylaxis presents with progressive fatigue and dyspnea on exertion. Vital signs show HR 102/min, RR 18/min, BP 118/76 mmHg, and Temp 37°C. Laboratory studies reveal macrocytic anemia with hemoglobin 7.2 g/dL and elevated MCV of 108 fL. Reticulocyte count is inappropriately low. Peripheral blood smear shows no schistocytes. Which nucleoside reverse transcriptase inhibitor is most likely responsible?
- A)Efavirenz
- B)ZidovudineGABARITO
- C)Maraviroc
- D)Ritonavir
- E)Acyclovir
Explicação
Zidovudine is an NRTI that inhibits HIV reverse transcriptase after intracellular phosphorylation. It is known for bone marrow suppression, including macrocytic anemia, and has an important historical role in reducing maternal to fetal transmission. The pregna... Ver explicação completa e trilha adaptativa →